EXOME™: the Advanced Anotation and Sequence Analysis Tool

EXOME™, MGL's proprietary Sequence Analysis Tool is a sophisticated product designed and developed to provide optimised results and ease of use via a user-friendly interface. It is built around two basic premises – high accuracy of results and uncomplicated usability. EXOME™ also lets you schedule your tasks to bring the facility of parallel processing, first time in any bio-informatics software.

EXOME™ assists biologists analyse biological data like nucleotide sequences on factors such as sequence statistics, ORF locations, restriction enzyme sites and coding region identification etc. EXOME™ is also capable of conducting gene prediction analysis and oligomer searches.

Easy to handle and user-friendly graphical interfaces, assist users analyse sequence data on multiple parameters using a comprehensive multi-tasking window. This concurrent analysis of multiple sequences can even be set up in a scheduler for automatic processing. This subsequently allows you to take publication of high-quality prints of the results.

More on what you can do with EXOME™

• Import and export nucleotide and protein sequences
• Implement indel (insertion-deletion) operations (E.g. induce mutations) through user-friendly interfaces
• Analyze and annotate nucleotide sequence: Automated sequence composition, restriction mapping, ORF finding, predicting genes and coding regions, user defined pattern searches etc.
• Find gene-coding regions: Dual search outputs through Fourier Transform and Window analysis for sensitive and accurate prediction
• In-silico simulation of central dogma of molecular biology
• Analyze protein sequence: Sequence composition (Amino acid composition with grouping on the basis of physico-chemical characteristics), molecular weight, extinction coefficient, aliphatic index of protein etc.
• Predict and draw isoelectric point and hydropathy plot: For proteins from their amino acid sequences and detect conserved patterns in protein sequences through a link to the PROSITE dictionary
• Compare query sequences with other sequences: On the NCBI server (using the BLAST algorithm) or multiple sequence alignment with the Clustal W
• Design Primers for PCR: With selection of optimum primers based on a number of critical parameters
• Phylogenetic analysis through tree plot of related sequences
• Schedule analysis of multiple sequences simultaneously in a batch process.

The copyright algorithm "GeneScan" is the foundation of EXOME™. In the Fourier Transform analysis for instance, EXOME™ delivers sharper coding region identification and recognizes a higher number of probable genes with a level of accuracy and sensitivity few analytical tools can match.

EXOME™ owes its lucidity and ease-of-use to its unique architecture. Unlike other applications and tools, GeneScan is completely training-independent for the prediction of coding regions. Hence the system is "ready to go" as no preparatory training or database information needs to be imparted.